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KMID : 0545120160260091566
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Journal of Microbiology and Biotechnology
2016 Volume.26 No. 9 p.1566 ~ p.1569
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Flavonoid Glycosides Inhibit Sortase A and Sortase A-Mediated Aggregation of Streptococcus mutans, an Oral Bacterium Responsible for Human Dental Caries
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Yang Woo-Young
Kim Chang-Kwon
Ahn Chan-Hong
Kim Hee-Gyu
Shin Jong-Heon
Oh Ki-Bong
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Abstract
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Three flavonoids were isolated from dried flowers of Sophora japonica using repetitive column chromatography and high-performance liquid chromatography. The flavonoids were identified as rutin (1), quercetin-3’-O-methyl-3-O-α-L-rhamnopyranosyl(1 → 6)-β-D-glucopyranoside (2), and quercetin (3) on the basis of spectroscopic analysis and comparison of values reported in the literature. These compounds inhibited the action of sortase A (SrtA) from Streptococcus mutans, a primary etiologic agent of human dental caries. The onset and magnitude of inhibition of saliva-induced aggregation of S. mutans treated with compound 1 was comparable to that of untreated S. mutans with a deletion of the srtA gene.
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KEYWORD
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Sophora japonica, flavonoids, Streptococcus mutans, sortase A, cell aggregation
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